When recently setting up a new development environment (with SP2 + AugCU) I noticed that I was not able to save, publish or checkin projects. On investigation, I found that the project server services were not running. If you ever encounter a similar situation, it may be as result of services timing out when starting project server. There are couple of registry changes that can be applied to resolve this issue. Refer to earlier post ‘New EPM2007 Deployment with SP2 – Issues with Services not starting’ for details.
Hope this helps.